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Nobody knows when a person gets addicted to painkillers. Everybody takes them to ease the pain related to diseases, fatigue after strenuous work or to overcome post surgery trauma. Still, for some people while they may have started using these medicines for valid reasons, the risk of addiction is always there.

This addiction, once it enters your life will overpower your other desires and ruin it forever. Since this addiction comes most silently, many people realize its bad consequences only when it is too late for them. These painkillers work on the principle of depressing the central nervous system and thus suppressing pain, so they become the first choice in managing pain.

Many painkillers use opium as a main ingredient, which when taken as a pill ceases any painful sensation in human body. In fact opium works on certain regions of the human brain that control the feeling of pleasure. This sometimes works as a great high for people in pain and thus makes them addicted to painkillers.

On experiencing the ill effects of painkillers when people desperately try to search for non-drug alternatives for pain relief, they usually face a much harder time in gaining access to them. So in desperation they turn towards painkillers which are easily available which fuels their addiction.

If any of your near and dear ones are prescribed with painkillers, then you should be very particular that the doses are to be taken only as prescribed. If disease treatment requires long term administration of painkillers then in consultation with physician, drug rotation needs to be done to avoid addiction to a particular drug. Similarly painkillers dosage must never be increased or decreased without doctor’s advice. As with any medicine, treatment with painkillers must never be abruptly discontinued on your own and the doctor’s advice must always prevail in such situations.

Due to prescription by a doctor, if a painkiller has been advised for certain duration, then that duration must strictly be adhered to. Exceeding that duration and taking that painkiller for a longer period could lead to addiction. Painkillers should be taken in tablet/ capsule form as they are available in market and should never be crushed. Crushing a large dose could be released in the human body leading to severely toxic effect. These drugs are manufactured in a certain way which ensures that they are to be released slowly in our system.

Precautions must always be taken to use a painkiller which has not been prescribed to you by a doctor. Painkillers purchased over the counter may turn out to be counterproductive as their effect varies from person to person according to his or her tolerance level and also due to the other drugs he or she may be using.

Endorphins, the body’s natural pain killers and exercise

The word is derived from endogenous ( inside the body) and morphine( morphine like effect)

Hence , endorphins are chemicals produced by the brain during certain periods that have effects similar to morphine and other opioid drugs. They however, do not cause dependence and addiction like the drugs.

Another significant difference is with regard to the duration of action. Endorphins ( which are made up of smaller subunits of proteins called peptides ) are rapidly degraded by the body’s enzymes unlike externally administered drugs which tend to act for long periods.

Their effect is brought about by activating certain receptors and modifying the transmission of other chemicals that communicate between nerve cells. Endorphins are most commonly released during periods of pain and stress.

In addition to lowering pain, they also have several positive effects on mood and even boost the immune system. This has potential implications in management of precancerous cells and research is going on in this regard.

Mood elevating effects are commonly seen after exercise and is the basis of the term ‘runners high’ .

While the extent of endorphins’ contribution to this is still a matter of debate among scientists, what is clear is that endorphins are found in higher concentration after bouts of exercise.

Typically, half an hour of continuous, moderately intense exercise releases endorphins.

For those less inclined to strenuous athletic activity , there is good news.

Other triggers for endorphin release include eating chocolates or chillies, sex, massage, acupuncture, laughter and meditation.

Its another known fact that endorphin levels differ among people. Apart from resting levels, the amount of activity required or the duration of the response also varies tremendously.

In another promising research area , similar pathways to the endogenous opioid system have been discovered with even more wide ranging effects such as memory , anxiety , sleep and appetite. Potential drugs targeting these areas are of great promise and indeed exciting times are ahead.

We now have yet another reason to exercise regularly. If nothing else, it simply makes us feel good and increases our immunity.

Care must be taken however , not to overdo it. High endurance and intensity exercises done for long periods of time ( for eg. triathlons and marathons ) results in the body also producing steroids to cope with the stress, thereby temporarily decreasing immunity. In such cases , enough time should be given for rest and recovery.

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Pain Medication-Is it worth it?

With all the hullabaloo surrounding the unwanted effects of pain medication, its only normal that you treat your over-the-counter(OTC) medicines with suspicion. A little basic knowledge, therefore, can help the average consumer make an informed decision and avoid the dangers of taking the wrong medication.

Classification of OTC pain medication

If you look at the pain relief medicine cabinet at any pharmacy store, you’d be forgiven for thinking that there are a large number of options available. But actuality, there are only three types of pain relievers currently available OTC. They are

1. Aspirin- Aspirin hinders the activity of the pain hormones, called prostaglandins, which would otherwise send pain information to the brain. Moreover, by blocking prostaglandins, aspirin reduces the pain and discomfort of inflammation.

2. Acetaminophen-Acetaminophen is found in drugs like Tylenol, as well as some fairly common OTC medications and in prescription pain-relief products. Acetaminophen travels through the blood vessels to the brain, reducing pain-related brain activity and fever. It isn’t quite as effective as the other two types of pain relievers at reducing inflammation or providing relief as it doesn’t work through the hormonal system.

3. Non-steroidal anti-inflammatories- These are sometimes called NSAIDs (pronounced N-Saidz). It  isn’t a single chemical, like acetaminophen, but a number of chemicals including ibuprofen, naproxen and ketoprofen, among others, all of which block the production of prostaglandins, thus alleviating pain and swelling. Some NSAIDs such as Aleve, Ibuprofen (generic) and Motrin are available over the counter; some newer NSAIDs, like Celebrex and Vioxx , require a prescription.

Tips to take Aspirin safely

Other than helping block the pain signals from the brain, aspirin also aids in blocking production of clots. Clots in the brain’s blood vessels can cause strokes, so aspirin is often prescribed to high risk patients to reduce chances of strokes.
This very property of aspirin also means that its difficult to stop bleeding if the person is taking aspirin. Pregnant women run a heightened risk of internal bleeding if they are on aspirin, so they should consult their doctor for a safer alternative.

Aspirin can also cause ulcer formation and gastric bleeding. While the enteric coating reduces chances of harm, aspirin shouldn’t be taken for a prolonged period of time without the assent of healthcare personnel.

Children and teenagers with viral illnesses should not be given aspirin without consulting a physician as certain virus and aspirin can lead to a potentially fatal complication called Reye’s syndrome.

Tips to take Acetaminophen safely

Acetaminophen can cause liver damage and finally liver failure, if taken in high doses over prolonged periods of time. Because there is a risk of overdose, children should never be given high strength acetaminophen. They should be given regular doses. If the person thinks that they have taken an overdose, they should call a doctor immediately.

Alcohol magnifies the effect of acetaminophen on the liver. If the person in question consumes alcohol regularly, they should consult a physician before taking acetaminophen, or any other pain reliever, for that matter.

Tips to take NSAIDs safely

NSAIDs elevate the risk of bleeding. In addition, they can also affect liver function and general health and result in gastrointestinal bleeding.

In order to steer clear of the aforementioned effects, patients shouldn’t take more than one NSAID at a time, or an NSAID with aspirin, without consulting with a healthcare professional. Patients should ensure that the medications they’re already on, do not contain an NSAID, before taking an NSAID separately.

Finally, pregnant and nursing women must consult with their doctor before using an OTC NSAID or any pain killer.

General tips

If a patient finds himself/herself taking a pain reliever over a prolonged period of time, they should check with their doctor as soon as possible. It is possible that the pain is a result of some other deep set disease. In that case, it is advisable that the underlying condition be treated, rather than subside the pain temporarily.

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